Thesis (Ph.D.)--University of Toronto, 1997.
|Statement||by Fina Liu.|
|The Physical Object|
|Number of Pages||125|
During early skeletal development, Runx2 is expressed by cells of the osteoblast lineage but not in fully differentiated chondrocytes Ducy, ). Thus, Runx2 expression is restricted to Author: Patricia Ducy. Building strong bones: Molecular regulation of the osteoblast lineage. Nature reviews Article Literature Review in Nature Reviews Molecular Cell Biology 13(1) December with ReadsAuthor: Fanxin Long. The preceding outlined studies expanded our understanding of the mesenchymal cell hierarchy and provided some insight into recognizable stages in the restricted osteoblast lineage, but they did not help to identify how many steps are in the pathway (see Fig. 2), how cells at each step differ, and what each kind of cell responds major problem continues to be the inability to identify Cited by: Pacheco E., Hu R., Taylor S. () Laser Capture Microdissection and Transcriptional Analysis of Sub-Populations of the Osteoblast Lineage from Undecalcified Bone. In: Murray G. (eds) Laser Capture Microdissection. Methods in Molecular Biology, vol Humana Press, New York, NY. First Online 18 January Author: Efrain Pacheco, Rong Hu, Scott Taylor.
Fina Liu has written: 'Molecular and cellular analysis of the osteoblast lineage' Asked in Human Anatomy and Physiology, Genetics, Skeletal System What is the effect of osteoclast cells on blood. Molecular biology of bone remodelling. Nadia Rucci. bone loss and osteoporosis are the result of an increased osteoclast function and/or a reduced osteoblast activity. In contrast, other pathologies are related to osteoclast failure to resorbe bone, such as osteopetrosis, a rare genetic disorder characterized by an increased bone mass and. Osteoblasts are the major cellular component of bone. Osteoblasts arise from mesenchymal stem cells (MSC). MSC give rise to osteoblasts, adipocytes, and myocytes among other cell types. Osteoblast quantity is understood to be inversely proportional to that of marrow adipocytes which comprise marrow adipose tissue (MAT).Function: Formation of bone tissue. Lee KS et al () Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C Mol Cell Biol 20(23)– PubMed Google ScholarCited by:
During zebrafish fin regeneration, blastema cells lining the epidermis differentiate into osteoblasts and joint cells to reconstruct the segmented bony rays. We show that osteoblasts and joint cells originate from a common cell lineage, but are committed to different cell fates. Pre-osteoblasts expressing runx2a/b commit to the osteoblast lineage upon expressing sp7, whereas the strong Cited by: 6. Evidence shows that age-related osteoporosis develops in association with reduced bone formation and increased marrow fat accumulation [4,5,6,7].During osteoporosis development, bone marrow mesenchymal stem cells (MSCs) exhibit reduced capacity to differentiate into osteoblasts and an increased capacity to differentiate into adipocytes, which results in a reduction in bone formation and Cited by: Comparing molecular fingerprints of skeletal cells suggests evolution of the osteoblast among vertebrate hed collagen and transcription factor gene expression in various vertebrate clades reveals variation in the molecular fingerprint of the osteoblast (red text), whereas the chondrocyte shows a conserved molecular by: Western blot analysis is used to study the activation of extracellular signal-regulated kinase (ERK1/2). Interestingly, butein promotes the lineage commitment of mBMSCs into osteoblasts, while suppressing their differentiation into adipocytes in a dose-dependent manner. A similar effect of butein is confirmed in human (h) primary BMSCs.